Potassium Magnesium Aspartate

Magnesium-Potassium aspartate is a mineral transporter where magnesium is bound to two molecules of the amino acid aspartic acid.  Aspartic acid is a nonessential amino acid that is very important in detoxification of ammonia, and in cellular energy production in the mitochondria. This type of mineral transporter efficiently carries magnesium and potassium to virtually all the cells of the body; but liver, muscles, heart, breast and glandular tissues have the best uptake. Since this compound is absorbed intact through the cells of the small intestine, the whole compound enters the blood stream. Upon uptake by the target cells the mineral is released inside the cell membrane activating membrane bound magnesium dependent enzymes.


Virtually all the magnesium in the body is contained inside of cells (intracellular). Many conditions can cause intracellular depletion or deficiency of magnesium including physical and emotional stress, malabsorption, chronic diarrhea, diets low in magnesium (processed and fast foods), excessive excretion can occur due to alcohol use or having diabetes. When a person is stressed the body will lose magnesium, zinc, vitamin C and B-vitamins in the urine. The correction of intracellular magnesium deficiencies with use of magnesium transporters such as magnesium orotate, magnesium arginate and potassium-magnesium aspartate can improve energy production, membrane transport of nutrients, protein synthesis and cell hydration.


In 1959 Laborit, who was a French scientist, wrote a scientific study where he expressed the idea that an important and often overlooked cause of fatigue was caused by insufficient energy production at a cellular level due to a lack of critical nutritive substances like magnesium and potassium. Studies soon thereafter began first in rats and then in humans that showed that use of potassium – magnesium aspartate 500 mg 2-4 tablets twice a day reduced fatigue and increased energy significantly after 5-14 days of use.


Studies show magnesium-potassium aspartate increases ATP formation (energy production) in the cells especially the skeletal muscles and the heart. The mineral is freed when the aspartic acid is incorporated into essential cellular metabolic processes. This mineral supplement is effective in relaxing skeletal muscles and the smooth muscles of the blood vessels, biliary tract, gastrointestinal tract, and the bronchial tree. Since this mineral transporter activates the enzymes involved in energy production, it can improve metabolism in the liver, muscles and the heart, and it can be useful in individuals with cardiovascular disease who have poor oxygen perfusion. According to Dr. Hans Nieper, the heart gets 50% of its energy from burning fatty acids and cardiac metabolism can be improved by combining magnesium mineral transporters (potassium –  magnesium aspartate 500 mg 2-3 twice a day and magnesium orotate 500 mg 3-4 tablets twice a day) along with selenium 200-400 mcg/day, vitamin B6 (pyridoxal – 5 – phosphate 50 mg/day), vitamin B1 (thiamine) 100-200 mg/day, lithium orotate 1-2 tablets/day and L-Carnitine 500 mg 2-4 capsules/day. He also used bromelain 2 tablets three times a day to keep the circulation open.


Magnesium mineral transporters such as potassium-magnesium aspartate, magnesium arginate and magnesium orotate can be useful in supporting metabolism both in heart muscle and in the conducting system of the heart. These magnesium mineral transporters can be helpful in supporting blood pressure. By activating the formation of high-energy phosphates in side of cells, especially ATP, potassium-magnesium aspartate helps increase the cells energy pool therefore overcoming muscular fatigue. Potassium-magnesium aspartate helps support glucose metabolism in diabetics, increases liver detoxification of ammonia and assists cardiac and skeletal muscle energy production in low oxygen conditions. Many athletes have found that use of Dr. Nieper’s magnesium mineral transporters improves their muscular performance, stamina and aerobic capacity.


Dr. Hans Nieper and Dr. Franz Kohler first prepared potassium magnesium aspartate in 1957.  Aspartate was chosen as the anionic carrier for the minerals potassium and magnesium for a variety of reasons.

  1. Aspartate was selected because of its role in intermediary metabolism.
  2. Binding potassium and magnesium cations to aspartate anions allowed for transport through the cellular membrane, a form of “active ion transport”
  3. This supplement was one of the first intracellular mineral transporters developed. A substance capable of penetrating the cell and freeing mineral cations for metabolism within.


The release of intracellular minerals magnesium and potassium addresses the issue of intracellular mineral deficiency particularly problematic in cardiovascular disorders.


Research has shown that individuals with suboptimal or deficiencies of potassium/ magnesium have increased risk of strokes, myocardial infarctions, hypertension and arrythmias and that replacement of these minerals intracellularly have beneficial effects of lowering morbidity in these conditions. This work confirmed the basic research done by Hans Selye in 1958-1961, which indicated that metabolic insufficiency of the myocardium, due to low oxygen states could be partially prevented by the protective action of potassium and magnesium through maintenance of cellular metabolism and stabilization of membrane electrical potential.


Biochemical Action

  1. Potassium magnesium aspartate normalizes metabolism in the presence of deficient

cellular oxygenation.

  1. Improves the pyruvate/lactate ratio which is a redox system.
  2. Aspartate salts increase serum concentration of alpha ketoglutarate indicating activation of tricarboxylic acid cycle enhancing ATP production.


Recommended Dosage

1.5 – 3.0 grams per day or 1-2 tablets 3 times per day.


Clinical Uses


  • Supports energy production in the heart even in low oxygen states.
  • Enhances liver function.
  • Reduces muscle atrophy secondary to low potassium.
  • Reduces muscle spasms secondary to low potassium.
  • Reduces fluid retention.
  • Improves intestinal movement.
  • Improves oxygen utilization in tissues after exercise, which leads to reduced fatigue.
  • Enhances ATP production by activating ATP forming enzymes.


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