Calcium  2 – AEP

Calcium 2-AEP plays a dual role both as a mineral carrier that releases calcium on the cell membrane surface and as a cell membrane repair material. Calcium 2-AEP was considered by Dr. Hans Nieper to be a cell membrane integrity factor that improved cell membrane functions. When the AEP is incorporated into the cell membrane, it binds fatty acids to preceding and following peptide chains in cell membranes helping in the repair of membrane structure. Calcium 2-AEP enhances normal membrane activity by assisting the cell membrane in maintaining its electronic function allowing for proper production of cellular capacitance. The capacitance of cell membranes is a reflection of the amount of charge in the membrane. Healthy cells are able to maintain their membrane charge (energy storage) whereas unhealthy and damaged cells have structural membrane abnormalities and imbalances of intracellular mineral concentrations, which results in lower membrane capacitance. One of the most important electronic roles of the cell membrane is creation of charge, maintenance of charge and the transfer of that charge to genetic material, which facilitates cellular protein synthesis. Reestablishing cell membrane structure in damaged cells and maintaining a healthy capacitance of the cell membranes is critical in the repair of damaged cells.

2-AEP is a nutritional supplement usually bound to calcium (calcium 2-AEP) or calcium, magnesium and potassium (2-AEP complex). 2-AEP is a cell membrane repair molecule that is a natural precursor of phosphatidylethanolamine. 2-AEP helps act as a cell membrane sealant reducing cell entry of toxins and viruses and it helps maintain and improve the electrical potential of cell membranes particularly in cells involved in inflammatory processes. In 1971, Monninghoff in Munster, Germany, published electron micrographs that revealed how AEP produced a sealing effect in cell membranes. Since the body is capable of manufacturing AEP it is not considered an essential nutrient. However, since both aging and inflammation results in the body being unable to produce enough natural AEP to protect the cells; it can be considered to be a conditionally essential nutrient.

Dr. Nieper felt that MS required special attention by researchers because of the long-suffering this disease causes in individuals who are afflicted with the illness. MS research was not Dr. Nieper’s original specialty. When he first started in practice he was orientated towards cancer therapy and using metabolic treatment for heart disease. He began treating MS patients in the 1960’s when his scientific research led him to discover that giving certain nutrients was an effective approach to MS. Dr. Nieper recognized that MS was not only a disease of nerve tissue, but that MS damaged cell membranes throughout the body.

Neural basics:

The nerve fibers that carry electrical impulses from the nerve cell body are called axons. In the central nervous system a multi-layered sheath called myelin or the myelin sheath surrounds axons. The myelin sheath in turn is created by a special nerve cell called an oligodendroglia cell. Myelin, historically, has been considered just an insulator.


Dr. Nieper approached MS from a completely unique new perspective. He recognized that myelin like other cell membranes have the capability of holding an electrical charge. Therefore, myelin fulfils the role of a biological capacitor.

Myelin is an extended wrapped cell membrane. Dr. Nieper recognized that AEP, a natural constituent of cell membranes, could also assist in the correct bonding of electrical charges to the cell membrane thus enhancing the biological capacitance of cell membranes. MS is a demyelinating disease where the myelin membrane coverings of nerve cell axons are damaged. When cell membranes are altered in structure by a deficiency of AEP in the membrane or the bonding of electrical charges is interfered with then the capacitance of the cell membrane will be below normal. Dr. Nieper believed that patients with autoimmune disorders have insufficient production of AEP. Autoimmune diseases, such as multiple sclerosis, in general have both genetic and environmental components. Dr. Nieper believed that is was likely that patients subject to autoimmune diseases make less AEP than other individuals. So when an environmental insult occurs to the nervous system these individuals are not able to repair the damage effectively resulting in the loss of cell membrane capacitance.

He believed that the loss of biological capacitance in the body’s cells resulted in patients feeling cold and subject to chills and in increased fragility of small blood vessels leading to easy bruising.

AEP is an important all membrane component. According to Dr. Nieper, AEP is necessary for the cell membrane to be able to bind electrical charges to the membrane. When AEP is deficient the cell membrane cannot properly bond electrical charges to the surface of the membrane, which results in a dysfunction of the cell membrane as a biological capacitor.

People with diabetes have trouble controlling high blood sugar. When blood sugar consistently stays too high it damages proteins and membranes throughout the body particularly in the kidneys, eyes, brain, nerves and arteries. Use of Calcium 2-AEP assists glucose transport into the cells. Dr. Nieper found that the use of AEP compounds would reduce damage to the small blood vessels in the eyes and nerves and would help protect the kidneys. An important observation is that the use of AEP increases the need for additional vitamin C. More vitamin C is assimilated as AEP is incorporated into cell membranes.

Recommended Dose:


Calcium 2-AEP 500 mg 3 capsules twice a day

Vitamin C 500 mg 1-2 twice a day




  1. Nieper HA. Mineral transporters. New Dynamics of Preventive Medicine; 1974: 43-54.
  2. Nieper HA. A clinical study of the calcium transport substance Ca l-d1-aspartate and Ca 2-aminoethyl phosphate as potent agents against autoimmunity and other anticytological aggressions. Agressologie. 1967, 8:1-12.
  3. Nieper HA. A comparative study of the clinical effect of Ca-1-d1-aspartate (Calciretard), of Ca-2-aminoethanol phosphate (Ca-EAP) and of the cortisones. Agressologie. 1968, 9: 471-474.
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